Preventable overdose deaths continue to impact our communities. We need to do better in behavioral healthcare at screening for and engaging individuals who are at risk for overdose: nearly 70% of patients who die by a prescription opioid overdose had been seen in a clinical setting within one month of death. We offer an evidence-informed overdose safety planning tool that can be integrated into behavioral and primary care clinical practice and scaled across multidisciplinary healthcare settings to help mitigate overdose risks through patient-centered engagement and support. Structured in the SBIRT model and rooted in principles of motivational interviewing, this tool includes essential steps and best practices for effective clinical approaches to harm reduction and overdose prevention, including best practices for use in integrated behavioral healthcare settings. Learn about the Zero Overdose safety planning tool and its applicability in clinical settings.