Transdiagnostic treatments are evidence-based in individual and group formats and can help efficiently treat a wide variety of mental health concerns. We adapted the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP), which incorporates cognitive-behavioral therapy and emotion science, for telehealth delivery as a brief group intervention (five 60-minute classes) for Primary Care Behavioral Health settings. We conducted a pilot open trial (N=18) to evaluate feasibility and acceptability as well as pre-post changes in mental health outcomes. Results suggested good feasibility, high acceptability, and promising signals of effectiveness, but further research is needed. Utilization of transdiagnostic treatments as well as telehealth and group formats may help to increase efficiency of and access to care.