CFHA’s technical assistance partnership with The Pew Charitable Trusts examined how federally qualified health centers (FQHCs) identify, engage, and treat patients with polysubstance use (PSU). The PEW-funded project combined landscape analysis, in-depth site visits and interviews, case studies from participating health centers, expert interviews, and a stakeholder convening to produce a summary report and practical TA resources for FQHCs and policy audiences. This session will present key findings from the work, describe replicable clinical and operational approaches for FQHCs, and offer an interactive discussion of TA tools CFHA developed to support implementation and scale-up. Polysubstance use is increasingly common in primary care panels and presents clinical, workflow, financing, and workforce challenges. FQHCs need practical, turnaround-ready strategies and targeted technical assistance to integrate PSU screening, intervention, medication and psychosocial treatments into team-based care.